diff --git a/llama_stack/core/datatypes.py b/llama_stack/core/datatypes.py
index faaeefd01..137dd5e13 100644
--- a/llama_stack/core/datatypes.py
+++ b/llama_stack/core/datatypes.py
@@ -40,6 +40,7 @@ RoutingKey = str | list[str]
 class RegistryEntrySource(StrEnum):
     via_register_api = "via_register_api"
     listed_from_provider = "listed_from_provider"
+    from_config = "from_config"
 
 
 class User(BaseModel):
diff --git a/llama_stack/core/routing_tables/common.py b/llama_stack/core/routing_tables/common.py
index ca2f3af42..48a6250a5 100644
--- a/llama_stack/core/routing_tables/common.py
+++ b/llama_stack/core/routing_tables/common.py
@@ -191,7 +191,14 @@ class CommonRoutingTableImpl(RoutingTable):
         if not is_action_allowed(self.policy, "delete", obj, user):
             raise AccessDeniedError("delete", obj, user)
         await self.dist_registry.delete(obj.type, obj.identifier)
-        await unregister_object_from_provider(obj, self.impls_by_provider_id[obj.provider_id])
+
+        # Only try to unregister from provider if the provider still exists
+        if obj.provider_id in self.impls_by_provider_id:
+            await unregister_object_from_provider(obj, self.impls_by_provider_id[obj.provider_id])
+        else:
+            logger.debug(
+                f"Provider {obj.provider_id} no longer exists, skipping provider unregistration for {obj.identifier}"
+            )
 
     async def register_object(self, obj: RoutableObjectWithProvider) -> RoutableObjectWithProvider:
         # if provider_id is not specified, pick an arbitrary one from existing entries
@@ -254,6 +261,13 @@ async def lookup_model(routing_table: CommonRoutingTableImpl, model_id: str) ->
     if model is not None:
         return model
 
+    # Check from_config models if this is a ModelsRoutingTable
+    if hasattr(routing_table, "_generate_from_config_models"):
+        from_config_models = routing_table._generate_from_config_models()
+        for from_config_model in from_config_models:
+            if from_config_model.identifier == model_id:
+                return from_config_model
+
     logger.warning(
         f"WARNING: model identifier '{model_id}' not found in routing table. Falling back to "
         "searching in all providers. This is only for backwards compatibility and will stop working "
diff --git a/llama_stack/core/routing_tables/models.py b/llama_stack/core/routing_tables/models.py
index b6141efa9..54ff580c8 100644
--- a/llama_stack/core/routing_tables/models.py
+++ b/llama_stack/core/routing_tables/models.py
@@ -12,6 +12,7 @@ from llama_stack.apis.models import ListModelsResponse, Model, Models, ModelType
 from llama_stack.core.datatypes import (
     ModelWithOwner,
     RegistryEntrySource,
+    StackRunConfig,
 )
 from llama_stack.log import get_logger
 
@@ -22,6 +23,7 @@ logger = get_logger(name=__name__, category="core::routing_tables")
 
 class ModelsRoutingTable(CommonRoutingTableImpl, Models):
     listed_providers: set[str] = set()
+    current_run_config: "StackRunConfig | None" = None
 
     async def refresh(self) -> None:
         for provider_id, provider in self.impls_by_provider_id.items():
@@ -74,6 +76,7 @@ class ModelsRoutingTable(CommonRoutingTableImpl, Models):
         provider_id: str | None = None,
         metadata: dict[str, Any] | None = None,
         model_type: ModelType | None = None,
+        source: RegistryEntrySource = RegistryEntrySource.via_register_api,
     ) -> Model:
         if provider_id is None:
             # If provider_id not specified, use the only provider if it supports this model
@@ -106,7 +109,7 @@ class ModelsRoutingTable(CommonRoutingTableImpl, Models):
             provider_id=provider_id,
             metadata=metadata,
             model_type=model_type,
-            source=RegistryEntrySource.via_register_api,
+            source=source,
         )
         registered_model = await self.register_object(model)
         return registered_model
@@ -117,6 +120,61 @@ class ModelsRoutingTable(CommonRoutingTableImpl, Models):
             raise ModelNotFoundError(model_id)
         await self.unregister_object(existing_model)
 
+    async def cleanup_disabled_provider_models(self) -> None:
+        """Remove models from providers that are no longer enabled in the current run config."""
+        if not self.current_run_config:
+            return
+
+        # Get enabled provider IDs from the current run config
+        enabled_provider_ids = set()
+        for _api, providers in self.current_run_config.providers.items():
+            for provider in providers:
+                if provider.provider_id and provider.provider_id != "__disabled__":
+                    enabled_provider_ids.add(provider.provider_id)
+
+        # Get all existing models
+        existing_models = await self.get_all_with_type("model")
+
+        # Find models from disabled providers (excluding user-registered models)
+        models_to_remove = []
+        for model in existing_models:
+            if model.provider_id not in enabled_provider_ids and model.source != RegistryEntrySource.via_register_api:
+                models_to_remove.append(model)
+
+        # Remove the models
+        for model in models_to_remove:
+            logger.info(f"Removing model {model.identifier} from disabled provider {model.provider_id}")
+            await self.unregister_object(model)
+
+    async def register_from_config_models(self) -> None:
+        """Register from_config models from the current run configuration."""
+        if not self.current_run_config:
+            return
+
+        # Register new from_config models (old ones automatically disappear since they're not persisted)
+        for model_input in self.current_run_config.models:
+            # Skip models with disabled providers
+            if not model_input.provider_id or model_input.provider_id == "__disabled__":
+                continue
+
+            # Generate identifier
+            if model_input.model_id != (model_input.provider_model_id or model_input.model_id):
+                identifier = model_input.model_id
+            else:
+                identifier = f"{model_input.provider_id}/{model_input.provider_model_id or model_input.model_id}"
+
+            model = ModelWithOwner(
+                identifier=identifier,
+                provider_resource_id=model_input.provider_model_id or model_input.model_id,
+                provider_id=model_input.provider_id,
+                metadata=model_input.metadata,
+                model_type=model_input.model_type or ModelType.llm,
+                source=RegistryEntrySource.from_config,
+            )
+
+            # Register the model (will be cached in memory but not persisted to disk)
+            await self.dist_registry.register(model)
+
     async def update_registered_models(
         self,
         provider_id: str,
diff --git a/llama_stack/core/stack.py b/llama_stack/core/stack.py
index 7ab8d2c64..a13cd0211 100644
--- a/llama_stack/core/stack.py
+++ b/llama_stack/core/stack.py
@@ -101,6 +101,15 @@ TEST_RECORDING_CONTEXT = None
 
 
 async def register_resources(run_config: StackRunConfig, impls: dict[Api, Any]):
+    # Set the run config on the models routing table for generating from_config models
+    if Api.models in impls:
+        models_impl = impls[Api.models]
+        models_impl.current_run_config = run_config
+        # Clean up models from disabled providers
+        await models_impl.cleanup_disabled_provider_models()
+        # Register from_config models
+        await models_impl.register_from_config_models()
+
     for rsrc, api, register_method, list_method in RESOURCES:
         objects = getattr(run_config, rsrc)
         if api not in impls:
@@ -118,7 +127,16 @@ async def register_resources(run_config: StackRunConfig, impls: dict[Api, Any]):
             # we want to maintain the type information in arguments to method.
             # instead of method(**obj.model_dump()), which may convert a typed attr to a dict,
             # we use model_dump() to find all the attrs and then getattr to get the still typed value.
-            await method(**{k: getattr(obj, k) for k in obj.model_dump().keys()})
+            kwargs = {k: getattr(obj, k) for k in obj.model_dump().keys()}
+
+            # Skip registering from_config models since they are registered through the routing table's set_run_config
+            if rsrc == "models":
+                logger.debug(
+                    f"Skipping registration of from_config model {obj.model_id} - will be registered through routing table"
+                )
+                continue
+
+            await method(**kwargs)
 
         method = getattr(impls[api], list_method)
         response = await method()
diff --git a/llama_stack/core/store/registry.py b/llama_stack/core/store/registry.py
index a764d692a..d1243cf33 100644
--- a/llama_stack/core/store/registry.py
+++ b/llama_stack/core/store/registry.py
@@ -102,6 +102,11 @@ class DiskDistributionRegistry(DistributionRegistry):
                 f"Object {existing_obj.type}:{existing_obj.identifier}'s {existing_obj.provider_id} provider is being replaced with {obj.provider_id}"
             )
 
+        # Skip persistence for from_config objects - they should only exist in memory
+        if hasattr(obj, "source") and obj.source == "from_config":
+            logger.debug(f"Skipping persistence for from_config object {obj.type}:{obj.identifier}")
+            return True
+
         await self.kvstore.set(
             KEY_FORMAT.format(type=obj.type, identifier=obj.identifier),
             obj.model_dump_json(),