diff --git a/docs/source/distributions/configuration.md b/docs/source/distributions/configuration.md
index 335fa3a68..c9677b3b6 100644
--- a/docs/source/distributions/configuration.md
+++ b/docs/source/distributions/configuration.md
@@ -225,8 +225,32 @@ server:
   port: 8321  # Port to listen on (default: 8321)
   tls_certfile: "/path/to/cert.pem"  # Optional: Path to TLS certificate for HTTPS
   tls_keyfile: "/path/to/key.pem"    # Optional: Path to TLS key for HTTPS
+  cors: true  # Optional: Enable CORS (dev mode) or full config object
 ```
 
+### CORS Configuration
+
+CORS (Cross-Origin Resource Sharing) can be configured in two ways:
+
+**Local development** (allows localhost origins only):
+```yaml
+server:
+  cors: true
+```
+
+**Explicit configuration** (custom origins and settings):
+```yaml
+server:
+  cors:
+    allow_origins: ["https://myapp.com", "https://app.example.com"]
+    allow_methods: ["GET", "POST", "PUT", "DELETE"]
+    allow_headers: ["Content-Type", "Authorization"]
+    allow_credentials: true
+    max_age: 3600
+```
+
+When `cors: true`, the server enables secure localhost-only access for local development. For production, specify exact origins to maintain security.
+
 ### Authentication Configuration
 
 > **Breaking Change (v0.2.14)**: The authentication configuration structure has changed. The previous format with `provider_type` and `config` fields has been replaced with a unified `provider_config` field that includes the `type` field. Update your configuration files accordingly.
@@ -618,6 +642,54 @@ Content-Type: application/json
 }
 ```
 
+### CORS Configuration
+
+Configure CORS to allow web browsers to make requests from different domains. Disabled by default.
+
+#### Quick Setup
+
+For development, use the simple boolean flag:
+
+```yaml
+server:
+  cors: true  # Auto-enables localhost with any port
+```
+
+This automatically allows `http://localhost:*` and `https://localhost:*` with secure defaults.
+
+#### Custom Configuration
+
+For specific origins and full control:
+
+```yaml
+server:
+  cors:
+    allow_origins: ["https://myapp.com", "https://staging.myapp.com"]
+    allow_credentials: true
+    allow_methods: ["GET", "POST", "PUT", "DELETE"]
+    allow_headers: ["Content-Type", "Authorization"]
+    allow_origin_regex: "https://.*\\.example\\.com"  # Optional regex pattern
+    expose_headers: ["X-Total-Count"]
+    max_age: 86400
+```
+
+#### Configuration Options
+
+| Field                | Description                                    | Default |
+| -------------------- | ---------------------------------------------- | ------- |
+| `allow_origins`      | List of allowed origins. Use `["*"]` for any. | `["*"]` |
+| `allow_origin_regex` | Regex pattern for allowed origins (optional). | `None`  |
+| `allow_methods`      | Allowed HTTP methods.                          | `["*"]` |
+| `allow_headers`      | Allowed headers.                               | `["*"]` |
+| `allow_credentials`  | Allow credentials (cookies, auth headers).    | `false` |
+| `expose_headers`     | Headers exposed to browser.                   | `[]`    |
+| `max_age`            | Preflight cache time (seconds).               | `600`   |
+
+**Security Notes**:
+- `allow_credentials: true` requires explicit origins (no wildcards)
+- `cors: true` enables localhost access only (secure for development)
+- For public APIs, always specify exact allowed origins
+
 ## Extending to handle Safety
 
 Configuring Safety can be a little involved so it is instructive to go through an example.
diff --git a/llama_stack/core/datatypes.py b/llama_stack/core/datatypes.py
index a1b6ad32b..c3940fcbd 100644
--- a/llama_stack/core/datatypes.py
+++ b/llama_stack/core/datatypes.py
@@ -318,6 +318,41 @@ class QuotaConfig(BaseModel):
     period: QuotaPeriod = Field(default=QuotaPeriod.DAY, description="Quota period to set")
 
 
+class CORSConfig(BaseModel):
+    allow_origins: list[str] = Field(default_factory=list)
+    allow_origin_regex: str | None = Field(default=None)
+    allow_methods: list[str] = Field(default=["OPTIONS"])
+    allow_headers: list[str] = Field(default_factory=list)
+    allow_credentials: bool = Field(default=False)
+    expose_headers: list[str] = Field(default_factory=list)
+    max_age: int = Field(default=600, ge=0)
+
+    @model_validator(mode="after")
+    def validate_credentials_config(self) -> Self:
+        if self.allow_credentials and (self.allow_origins == ["*"] or "*" in self.allow_origins):
+            raise ValueError("Cannot use wildcard origins with credentials enabled")
+        return self
+
+
+def process_cors_config(cors_config: bool | CORSConfig | None) -> CORSConfig | None:
+    if cors_config is False or cors_config is None:
+        return None
+
+    if cors_config is True:
+        # dev mode: allow localhost on any port
+        return CORSConfig(
+            allow_origins=[],
+            allow_origin_regex=r"https?://localhost:\d+",
+            allow_methods=["GET", "POST", "PUT", "DELETE", "OPTIONS"],
+            allow_headers=["Content-Type", "Authorization", "X-Requested-With"],
+        )
+
+    if isinstance(cors_config, CORSConfig):
+        return cors_config
+
+    raise ValueError(f"Expected bool or CORSConfig, got {type(cors_config).__name__}")
+
+
 class ServerConfig(BaseModel):
     port: int = Field(
         default=8321,
@@ -349,6 +384,12 @@ class ServerConfig(BaseModel):
         default=None,
         description="Per client quota request configuration",
     )
+    cors: bool | CORSConfig | None = Field(
+        default=None,
+        description="CORS configuration for cross-origin requests. Can be:\n"
+        "- true: Enable localhost CORS for development\n"
+        "- {allow_origins: [...], allow_methods: [...], ...}: Full configuration",
+    )
 
 
 class StackRunConfig(BaseModel):
diff --git a/llama_stack/core/server/server.py b/llama_stack/core/server/server.py
index 3d94b6e81..350ce0052 100644
--- a/llama_stack/core/server/server.py
+++ b/llama_stack/core/server/server.py
@@ -28,6 +28,7 @@ from aiohttp import hdrs
 from fastapi import Body, FastAPI, HTTPException, Request, Response
 from fastapi import Path as FastapiPath
 from fastapi.exceptions import RequestValidationError
+from fastapi.middleware.cors import CORSMiddleware
 from fastapi.responses import JSONResponse, StreamingResponse
 from openai import BadRequestError
 from pydantic import BaseModel, ValidationError
@@ -40,6 +41,7 @@ from llama_stack.core.datatypes import (
     AuthenticationRequiredError,
     LoggingConfig,
     StackRunConfig,
+    process_cors_config,
 )
 from llama_stack.core.distribution import builtin_automatically_routed_apis
 from llama_stack.core.external import ExternalApiSpec, load_external_apis
@@ -483,6 +485,12 @@ def main(args: argparse.Namespace | None = None):
             window_seconds=window_seconds,
         )
 
+    if config.server.cors:
+        logger.info("Enabling CORS")
+        cors_config = process_cors_config(config.server.cors)
+        if cors_config:
+            app.add_middleware(CORSMiddleware, **cors_config.model_dump())
+
     if Api.telemetry in impls:
         setup_logger(impls[Api.telemetry])
     else:
diff --git a/tests/unit/server/test_cors.py b/tests/unit/server/test_cors.py
new file mode 100644
index 000000000..8fd2515ba
--- /dev/null
+++ b/tests/unit/server/test_cors.py
@@ -0,0 +1,105 @@
+# Copyright (c) Meta Platforms, Inc. and affiliates.
+# All rights reserved.
+#
+# This source code is licensed under the terms described in the LICENSE file in
+# the root directory of this source tree.
+
+import pytest
+
+from llama_stack.core.datatypes import CORSConfig, process_cors_config
+
+
+def test_cors_config_defaults():
+    config = CORSConfig()
+
+    assert config.allow_origins == []
+    assert config.allow_origin_regex is None
+    assert config.allow_methods == ["OPTIONS"]
+    assert config.allow_headers == []
+    assert config.allow_credentials is False
+    assert config.expose_headers == []
+    assert config.max_age == 600
+
+
+def test_cors_config_explicit_config():
+    config = CORSConfig(
+        allow_origins=["https://example.com"], allow_credentials=True, max_age=3600, allow_methods=["GET", "POST"]
+    )
+
+    assert config.allow_origins == ["https://example.com"]
+    assert config.allow_credentials is True
+    assert config.max_age == 3600
+    assert config.allow_methods == ["GET", "POST"]
+
+
+def test_cors_config_regex():
+    config = CORSConfig(allow_origins=[], allow_origin_regex=r"https?://localhost:\d+")
+
+    assert config.allow_origins == []
+    assert config.allow_origin_regex == r"https?://localhost:\d+"
+
+
+def test_cors_config_wildcard_credentials_error():
+    with pytest.raises(ValueError, match="Cannot use wildcard origins with credentials enabled"):
+        CORSConfig(allow_origins=["*"], allow_credentials=True)
+
+    with pytest.raises(ValueError, match="Cannot use wildcard origins with credentials enabled"):
+        CORSConfig(allow_origins=["https://example.com", "*"], allow_credentials=True)
+
+
+def test_process_cors_config_false():
+    result = process_cors_config(False)
+    assert result is None
+
+
+def test_process_cors_config_true():
+    result = process_cors_config(True)
+
+    assert isinstance(result, CORSConfig)
+    assert result.allow_origins == []
+    assert result.allow_origin_regex == r"https?://localhost:\d+"
+    assert result.allow_credentials is False
+    expected_methods = ["GET", "POST", "PUT", "DELETE", "OPTIONS"]
+    for method in expected_methods:
+        assert method in result.allow_methods
+
+
+def test_process_cors_config_passthrough():
+    original = CORSConfig(allow_origins=["https://example.com"], allow_methods=["GET"])
+    result = process_cors_config(original)
+
+    assert result is original
+
+
+def test_process_cors_config_invalid_type():
+    with pytest.raises(ValueError, match="Expected bool or CORSConfig, got str"):
+        process_cors_config("invalid")
+
+
+def test_cors_config_model_dump():
+    cors_config = CORSConfig(
+        allow_origins=["https://example.com"],
+        allow_methods=["GET", "POST"],
+        allow_headers=["Content-Type"],
+        allow_credentials=True,
+        max_age=3600,
+    )
+
+    config_dict = cors_config.model_dump()
+
+    assert config_dict["allow_origins"] == ["https://example.com"]
+    assert config_dict["allow_methods"] == ["GET", "POST"]
+    assert config_dict["allow_headers"] == ["Content-Type"]
+    assert config_dict["allow_credentials"] is True
+    assert config_dict["max_age"] == 3600
+
+    expected_keys = {
+        "allow_origins",
+        "allow_origin_regex",
+        "allow_methods",
+        "allow_headers",
+        "allow_credentials",
+        "expose_headers",
+        "max_age",
+    }
+    assert set(config_dict.keys()) == expected_keys